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Diclofenac sodium, also known as Diclofenac, is an effective anti-inflammatory analgesic with wide application. As early as 1966, the synthesis of diclofenac sodium was first reported in Switzerland. Until 1974, the production of diclofenac sodium with benzoic acid as the raw material was first realized in industrial production. Diclofenac sodium has since become one of the top ten best-selling drugs in the world.
According to reports, after more than ten years, Prof. Chen Fenji invented diclofenac sodium with o-nitrotoluene as the starting material, phase transfer catalysis, polymer-dispersed palladium catalytic reduction, condensation, and aromatization. Synthesis of new technology, the yield of each step is more than 90%, the total yield of more than 88%. The process drastically reduced the raw material cost of diclofenac sodium and significantly improved the quality of the product, forcing Switzerland, Japan, the United States, Germany and other countries to suspend production and switching to importing such drugs from China. The technology invented by Prof. Chen Fenji has achieved industrial production in domestic pharmaceutical companies and has occupied 80% of the international market share.
A new method of synthesizing diclofenac drugs invented by Prof. Chen Fenji of the Department of Chemistry at Fudan University has broken through the traditional production processes that have been adopted at home and abroad for 30 years, has greatly reduced the emission of pollutants in production, and drastically reduced raw material costs. 1/2 of traditional craftsmanship.
October 20, 2023